Creative Biolabs, a biotechnology service provider specializing in immuno-oncology research, has announced an upcoming webinar titled 'Modeling T Cell Dysfunction in Tumor Microenvironments.' The live virtual event is scheduled for September 1, 2026, at 10:00 AM EDT, and will feature a keynote presentation by Greg M. Delgoffe, Ph.D., Professor of Immunology at the University of Pittsburgh and Director of the Tumor Microenvironment Center at the UPMC Hillman Cancer Center.
The webinar addresses a critical challenge in oncology: understanding the tumor microenvironment (TME), a complex ecosystem where cancer cells, immune cells, and metabolites interact. As tumors progress, they create a metabolically hostile environment characterized by nutrient depletion and accumulation of immunosuppressive byproducts. These metabolic pressures impair immune cell function, leading to T cell dysfunction, immune evasion, and reduced response to standard cancer immunotherapies.
Dr. Delgoffe will discuss innovative approaches to modeling these environments, emphasizing that traditional models often fail to capture the nuanced interactions between tumor metabolism and immune regulation. By utilizing advanced preclinical testing services and robust in vivo and in vitro models, researchers can better replicate metabolic stress conditions, providing valuable tools to investigate immune suppression and therapeutic responses under physiologically relevant conditions.
The webinar will cover several key topics: how tumor metabolic environments contribute to immune suppression and T cell exhaustion, strategies for modeling TME conditions in preclinical research systems, the mechanisms underlying T cell exhaustion and how nutrient depletion influences T cell function, and how immunometabolism insights can guide therapeutic strategies to enhance cancer immunotherapy.
'Understanding how metabolic conditions within tumors influence immune-cell behavior is increasingly important in immuno-oncology,' said a senior scientific director at Creative Biolabs. 'Dr. Delgoffe's work provides an important perspective on how researchers can model these conditions and investigate target discovery and validation.'
This webinar is particularly relevant for cancer immunology researchers, pharmaceutical and biotechnology professionals, and R&D teams dedicated to oncology drug discovery. For webinar details and registration, please visit the official registration page.
